AstraZeneca Pharmaceuticals LP Scientist, NGS Informatics, Oncology in Waltham, Massachusetts

Scientist, NGS Informatics, Oncology (Waltham, MA, USA)

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe. As a Scientist, NGS Informatics, Oncology in Waltham, MA, USA or Cambridge, UK you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas.

AstraZeneca’s vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the aim of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers. As well as other tumor types, these are being targeted through four key platforms - immunotherapy, the genetic drivers of cancer and resistance, DNA damage repair, and antibody drug conjugates, underpinned by personalized healthcare and biomarker technologies.

Main Duties and Responsibilities

There is an exciting opportunity for a talented and motivated bioinformatician, eager to bring NGS data together in new ways, to join the group as a Scientist. In this role, you will:

  • Manages, analyses, and deliver customer sequencing data.

  • Develops, tests, and supports data analysis tools and pipelines.

  • Ensure proper movement and automation of data from sequencer to data storage unit.

  • Validate the quality of the datasets using various tools to assess the correctness of the results.

  • Troubleshoot data quality issues by collaborating with Lab and other personnel.

  • Assists with developing requirements for internal software development.

  • Build and maintain high level of experience with team's software and IT technologies.

  • Work collaboratively with scientists and outside collaborators to cultivate, process, and analyse genomic information

  • Develop and maintain a in depth understanding of the scientific and technological domains supported by the NGS Informatics team.

  • Design and apply innovative computational/statistical algorithms and visualizations to: Generate actionable biological insight from genomic data.

  • Build and steer further development of small prototype tools for bench scientists to access and visualize genomic data. Finally, you will collaborate with industry and academia, and exploit external resources, to find the most effective solutions to problems.

Essential Requirements

  • Relevant MS/PHD degree (MS degree with 2+ years’ experience desirable)

  • An enthusiasm to explore non-traditional approaches to bring big data together in biologically meaningful ways.

  • Programming in a Unix and Windows environment.


  • A publication track record.

  • Networked within external bioinformatics and NGS communities.

  • An understanding of the contribution of bioinformatics to drug discovery.

  • Effective contributing to collaborative projects involving cross-disciplinary and global teams.

  • Awareness of graph modeling, machine learning, Bayesian analytics or other non-traditional approaches to model biological data.

  • Python/Perl programming expertise.

  • SQL/Database management expertise.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.