AstraZeneca Pharmaceuticals LP PostDoc Fellow - Respiratory Therapy Area in Waltham, Massachusetts

We're currently looking for talented scientists to join our growing team developing human relevant in vitro lung models (Organ-Chips) to develop our ability to understand disease biology and enhancing the efficacy and safety of our new medicines. This exciting opportunity will allow you to gain insights into basic cellular biology, cellular cross-talk, human physiology, mechanotransduction, molecular biology and bioengineering.

As part of our innovative academic-style Postdoc program, you will take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in the cutting edge laboratories of our partners Emulate. You’ll therefore be exposed to both a global pharmaceutical environment and to a unique innovative R&D environment working with biologists, engineers, and designers.

What’s more, you’ll have the support of a leading advisor at Emulate, who’ll provide you with the guidance and knowledge you need to develop your career. Organs-on-Chips technology is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science. Please note you will be based at Emulate's offices in Boston for the duration of the contract.

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, teams are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.

Targeting respiratory diseases is one of the three main therapeutic research areas within Innovative Medicines and Early Development (IMED), AstraZeneca’s small molecule biotech unit that deliver candidate drugs into late-stage clinical development. The diseases of interest, including asthma, Chronic Obstructive Pulmonary Disease (COPD) and interstitial pulmonary fibrosis (IPF) represent areas of high unmet medical needs where patients have a progressive loss in lung function, impaired quality of life and ultimately may die due to respiratory failure.

About Emulate

Emulate works at the intersection of biology, engineering, and design, developing technologies that emulate human biology. Their products are enabling a new era of precision medicine and the development of applications for personalized health.

Emulate's Human Emulation System, which uses Organs-on-Chips technology, is being used by industry, government, and academia to understand how different diseases, medicines, chemicals and foods affect human health. The system offers researchers a new standard for predicting human response — with greater precision and control than today’s cell culture or animal-based experimental methods.

Research conducted using Emulate's Organ-Chips has been published in high-impact scientific journals, including Science. Emulate's founding team pioneered the original Organs-on-Chips technology during their residency within the Wyss Institute for Biologically Inspired Engineering at Harvard University. To learn more visit emulatebio.com.

Responsibilities

Drive and carry out characterisation of advanced cell culture models

Innovate, design and implement improvements to the models

Devise disease models, test therapeutic agents and develop biomarker assays

Plan and write high impact publications

Present data internally and at external scientific meetings

Essential requirements, education and experience:

PhD or equivalent in a relevant area

Experience of working with primary cell cultures

Experience of in vitro models of lung disease

Experience of a range of standard biological techniques such as imaging and molecular biology

Desirable requirements, education and experience:

Experience of working with microphysiological systems or co-culture in vitro systems

Skills and Capabilities required:

Demonstrable ability to work to tight timelines

Excellent written and spoken English

Proven ability to produce publications

Good communication skills at a variety of levels

Independent researcher who can also work well in teams

To apply for this position, please click the apply below.

Advert opening date - 8th June 2018

Advert closing date - 30th June 2018

AstraZeneca welcomes applications from all sections of the community.

This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at Emulate's offices in Boston, USA with a competitive salary on offer

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, or protected veteran status and will not be discriminated against on the basis of disability.