AstraZeneca Pharmaceuticals LP In Vivo Sr. Scientist, Oncology Biosciences in Waltham, Massachusetts

In Vivo Sr. Scientist, Oncology Biosciences

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

Job Description:


We are seeking a highly motivated and creative individual to join a group of Oncology in vivo scientists at AstraZeneca. As an In VivoSenior Scientist, you will support AstraZeneca’s industry-leading drug portfolio within the Oncology In Vivo Biosciences Team. Based in our state of the art Biohub facility in Waltham MA, you will work in a cross-functional and highly matrixed environment and lead the in vivo pharmacology strategy and deliverables for both early and late stage projects to support the development of new and successful cancer therapies.

Key Responsibilities:

  • Design and deliver in vivo screening cascades to support lead optimization and candidate selection for new drug target programs.

  • Deliver comprehensive in vivo pharmacology data packages for drug candidates in early clinical development, including PK/PD and efficacy studies, dose and schedule optimization, and in vivo combination studies.

  • Work collaboratively with translational scientists to support patient selection strategies and identify biomarker response signatures.

  • Bring in new technologies and approaches to improve or replace existing disease model platforms that better predict clinical response.

  • Work collaboratively with colleagues to develop and implement aggressive work plans and timelines.

  • Mentor/supervise/train more junior lab scientists

Minimum Requirements:

  • MS or PhD in Pharmacology or related discipline, with a minimum of 2 years relevant experience, including experience in Biopharma.

  • Experience delivering all aspects of in vivo pharmacology studies in rodent tumor models, including dose-finding tolerability studies, PK/PD studies, and efficacy studies.

  • Experience developing and working with complex in vivo models of cancer, such as patient-derived xenograft models, humanized models of cancer, orthotopic xenograft models, and metastatic models of cancer.

  • Experience across multiple platforms to develop and analyze PD biomarker endpoints in tumors and tissues.

  • Strong track record of working across boundaries to deliver common goals.

  • Ability to lead from the bench in problem solving and in the development of innovative solutions.

  • Excellent communication and presentation skills

  • A proven track record of high productivity and scientific publications in peer reviewed journals.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

Next Steps – Apply today!

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AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.