AstraZeneca Pharmaceuticals LP Cell Biology Technician in Oss, Netherlands

Do you have experience with cell culture? Did you work with primary human tissue samples? Are you familiar with working with GCLP regulations? And do words like ‘accurate’ & ‘keep high quality standards’ fit your profile?

If so, please read on, because Acerta Pharma is looking for a new colleague for our small and strong Biology Team.

Cell Biology Technician

Oss

Fulltime (40 hours)

(Flexible to work outside office hours on occasional basis)

What are you going to do?

As a Cell Biology Technician you will play an integral role in the Biology functional team with members from the Biology groups in Oss and San Carlos in the US. You will support translational science activities by carrying out work up and analysis of clinical study patient samples as required for several Acerta oncology clinical trials, in accordance with GCLP regulations. For this position, flexibility is requested to participate in occasional out-of-hours work up of samples (divided between you and your colleagues).

This candidate will be vital to the successful expansion of the Translational Science group at the Oss site providing laboratory support for Acerta Pharma’s clinical trials carried out in Europe.

Your tasks & responsibilities:

  • Receive, process and test human tissue samples to measure pharmacodynamic effects and biomarkers.

  • Plan and execute on daily operations under the guidance of a senior scientist or line management.

  • Conduct development and implementation of sample preparation methods and pharmacodynamic/biomarker assays.

  • Participate in integrated translational science activities by engaging in interaction with scientists of different disciplines from Acerta Pharma as well as AstraZeneca/ MedImmune.

  • Participate in data analysis and preparation of data reports under the guidance of line management.

  • Maintain accurate and well-organized laboratory records, worksheets and notebooks in accordance with Acerta Pharma’s quality management system for working with clinical material.

  • Identify and communicate problems.

What do we ask from you?

The ‘must haves’:

  • You have a minimum of a Bachelor degree in Life Sciences or any other related study.

  • At least 1-year work experience in a pharmaceutical or academic research and/or development laboratory.

  • You have experience with in vitro cellular assays such as measuring viability, phenotype, proliferation, activation, differentiation and apoptosis using flow cytometry and ELISA techniques.

  • You value a high standard of quality, safety and environmental precautions.

  • Further you have a basic understanding of cell biology, preferably with a focus on oncology and cellular immunology.

  • Good command of English.

  • Meticulous, accurate, reliable, team player, pro-active.

  • Residence in the Netherlands, preferably living within 50 km from the office in Oss (for example: Nijmegen, Utrecht, Eindhoven)

The ‘nice to haves’

  • You have experience in working with primary human tissue samples and isolation of primary cells from blood or other tissues.

  • You have experience with multicolor flow cytometry.

  • Experience with GCLP.

  • Ability to critically evaluate experimental design and results.

  • Experience with data handling, analysis and archiving.

  • Effective written/oral communication skills.

What do we offer you?

  • The opportunity to develop yourself.

  • A dynamic, innovative, international working environment, to let you be a part of the development of the new medicines which can make the difference to the life of patients.

  • The possibility to work in a small, dedicated team where you can learn a lot from each other. The team spirit is very good!

  • The possibility to cooperate with your international colleagues from the translational science and clinical departments of Acerta Pharma in the US.

  • A good salary and good secondary benefits like: 8% holiday allowance, 25 holidays per year on a fulltime basis, collective pension with a fixed percentage, bonus package. We will offer you a one-year contract with the intention to extend it to a permanent contract.

The Team

The Translational Science Team is part of the Biology Team in Oss and consists of 4 colleagues, three Scientists and one Senior Research Scientist. In this position you will report to the Senior Research Scientist. We also work together closely with the Translational Science team located at the Acerta Pharma site in San Carlos. The culture is informal, a good team spirit, and willingness to share and to learn from each other. You work all for the same goal!

Acerta Pharma

Acerta Pharma B.V. was founded in 2012 by Allard Kaptein, Tjeerd Barf, Ahmed Hamdy, Raquel Izumi, and Francisco Salva. Acerta Pharma is a leader in the field of covalent binding technology and is applying this technology to create novel, highly selective therapies for cancer.

Around 200 people work at Acerta Pharma, divided over 3 locations, one at the Pivot Park in Oss in The Netherlands, and two in the US (San Carlos and South San Francisco). In Oss there are about 25 enthusiastic, inspired colleagues working every day on drug discovery and development, together with the teams in the US in order to bring new treatment options to patients.

After reporting highly promising data from a phase 1b/2a study in chronic lymphocytic leukemia patients in 2015, the company received a lot of attention. In February 2016, AstraZeneca acquired a majority share (55%) of Acerta Pharma and is a committed partner for the haematologic oncology field. At the end of October 2017, the US Food and Drug Administration (FDA) granted accelerated approval in the USA for acalabrutinib for previously treated mantle cell lymphoma (MCL) patients. Acerta Pharma together with AstraZeneca are now working hard towards approval for other countries and for additional indications for this drug.