AstraZeneca Pharmaceuticals LP Senior Scientist, Pharmaceutical Science in Macclesfield, United Kingdom

Senior Scientist, Pharmaceutical Science


At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

AstraZeneca is at a critical phase in the journey to deliver our bold ambition; to improve the lives of 200 million patients and be a $50 billion company in 2025. We are on track to deliver 10 new medicines by 2020, and we have one of the most exciting portfolios in the industry.

Pharmaceutical Sciences was established in the IMED organisation to implement intelligent design of medicines and delivery systems, and consists of three areas, Early Chemical Development, Early Product Development and Advanced Drug Delivery. Pharmaceutical sciences are responsible for the delivery of drug substance and formulations to support drug development projects from pre-clinical to Phase 2b across all the main therapy areas of interest to AstraZeneca. Early Chemical Development (ECD) is a multi-skilled collaborative group with expertise in organic synthesis and route design, process scale-up, analytical chemistry, crystallization science and process engineering, transforming laboratory scale synthesis to innovative processes capable of multi-kilo manufacture.

We are looking to recruit a chemist on a permanent basis to join our Process Chemistry Team in ECD based in Macclesfield UK. The successful applicant will be an enthusiastic, motivated and highly capable individual, able to work closely with analytical chemists, engineers, project managers and other scientists to contribute to Pharmaceutical Science projects, supporting project and portfolio progression.

You will be involved in designing and implementing new chemical processes with a focus on delivery of multi kilo amounts of active pharmaceutical ingredient (API) to meet demanding early phase project timelines. You will be responsible for delivering chemistry knowledge that encompasses some or all the following key drivers, depending on the stage of clinical development; speed, quality, cost, efficiency, measurement, control strategy, robustness and understanding, to ensure quality of material and knowledge of processes for toxicology trials and clinical evaluation.

Typical accountabilities for the successful applicant include:

  • Manages own work to achieve project targets in a timely fashion and to agreed quality standards by applying technical knowledge and expertise

  • Develops drug substance route and process for early supply of API

  • Oversees the manufacture of batches for discovery, pre-clinical or clinical use as required and reviews and oversees appropriate test methodology and specifications for these

  • Assesses, reviews and reports data from own work and work of junior colleagues, with a clear understanding of its reliability and interprets findings and draws authoritative conclusions and recommendations so that their significance can be appreciated

  • Applies technical knowledge to improvement projects and the evaluation of new technology/processes

  • Presents information for discussion at project teams and across other functions

  • May be expected to influence colleagues in other areas/functions and/or in external groups

  • Provides training/guidance to junior scientists on technical and functional processes

  • Works as a member of cross-functional teams, with a large degree of independence representing own department or area of expertise

  • Ensures own work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)

Requirements and Experience


  • A degree or PhD in Organic Chemistry with relevant industrial experience

  • Substantial experience in practical synthesis

  • An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques

  • The ability to think innovatively to drive improvement, and address issues when contributing to project strategies

Desirable Requirements

  • Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques

  • A record of publication

  • Proven laboratory team leadership skills

  • The ability to develop and analyse multiple solutions to problems

  • The confidence to coach and drive performance and development among your peers

Please note applications must include your current CV and a covering letter, which presents your motivation and suitability for the role.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.