AstraZeneca Pharmaceuticals LP DMPK Design Lead within Cardiovascular, Renal and Metabolism in Gothenburg, Sweden

Do you have expertise in medicinal chemistry, physical chemistry or biotransformation? Would you like to develop within drug metabolism and pharmacokinetics? Are you aiming to apply your expertise in a company that follow the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

We are now recruiting a DMPK Design Lead to join the DMPK department within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development (IMED), AstraZeneca’s biotech unit that delivers drug candidates into late-stage clinical development. CVRM is based in AstraZeneca’s world-class vibrant R&D centre, located in Gothenburg, Sweden. CVRM DMPK interacts with other functions to support CVRM projects all along the value chain, from target selection through launch and life cycle management.

Drug Metabolism and Pharmacokinetic (DMPK) Design Leader (DDL) is a strategic and scientific role where you, together with Medicinal Chemists and project representatives from other disciplines, influence chemical drug design to optimize the ADMET (absorption, distribution, metabolism, excretion, toxicity) properties of our future therapeutic drugs. It is your responsibility that the DMPK project team delivers the overall non-clinical DMPK, including pre-clinical PK, translational pharmacokinetic and pharmacodynamic relationships, biotransformation and bioanalysis to early drug projects from target selection to lead optimization and candidate drug selection. You are expected to have a solid understanding of DMPK and chemistry to be able to provide expert advice and interpretation of complex drug discovery data.

Main Duties and Responsibilities

  • Key Deliverables: Lead DMPK-related activities and the optimisation of compounds by balancing the properties associated with absorption, distribution, clearance, elimination and drug-drug interaction potential within agreed timelines and to the right quality

  • Accountable (together with Medicinal Chemistry, Bioscience and Safety) for compound design and effective cross-discipline optimization and Design-Make-Test-Analysis (DMTA) cycles in drug discovery

  • Apply an understanding of DMPK, physicochemical properties and biotransformation to support/influence compound design, project progression and project strategy

  • Use state of the art in silico tools (e.g. physicochemical models for DMPK predictions) to accelerate steps of the DMTA cycle

  • Lead DMPK-related activities in your drug project, including the use of bespoke experiments and predictive models to ensure that DMPK challenges are thoroughly assessed and resolved

  • Be up to date with emerging literature and continuously display scientific progress externally and internally

Essential Requirements

  • PhD or equivalent degree in relevant discipline (Medicinal, Organic or Physical Chemistry or Biotransformation).

  • Understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds.

  • Understanding of integrative aspects of DMPK and pharmacology/safety of drug discovery and development

  • Ability to engage and collaborate across boundaries with a problem solving attitude and delivery focus

If you are interested, apply now!

For more information about the position please contact Marie Ahlqvist at marie.ahlqvist@astrazeneca.com

Welcome with your application no later than June 10, 2018

AstraZeneca is a global, innovation-driven pharmaceutical company focussing on the discovery, development and commercialization of novel medicines. At AstraZeneca, we are proud to have a unique culture that inspires innovation and collaboration both within the company and with external partners. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.