AstraZeneca Pharmaceuticals LP Head of Lifecycle Management, Fasenra in Gaithersburg, Maryland
Benralizumab (FASENRA®) is the only humanized, afucosylated, immunoglobulin G1k (IgG1k) isotype monoclonal antibody that directly binds to the human interleukin‑5 receptor alpha (hIL-5Rα) on eosinophils and basophils. Benralizumab is uniquely engineered to recruit natural killer cells directly to its target, resulting in active apoptosis via antibody-dependent cellular cytotoxicity (ADCC).
The targeted mechanism of action of Benralizumab induces direct and near complete depletion of eosinophils in the airways, lung, sputum, blood, and bone marrow. Depletion of eosinophils is rapid and durable, with blood eosinophils completely depleted (0 cells/μL) 24 hours following subcutaneous dosing with benralizumab and which remain depleted during treatment with doses given every 8 weeks.
Fasenra is currently indicated as an add on treatment to standard of care for patients with eosinophilic Severe Uncontrolled Asthma with approval granted in US, EU, Japan and Canada at February 2018. Future indications are part of the clinical development plan and include COPD, Nasal Polyps (currently in Ph3) and other eosinophilic non-airways diseases such as EGPA, HES and EoE (currently being assessed)
Fasenra is the first launched respiratory biologic for AstraZeneca and represents one of the top company priorities within the respiratory TA and the overall portfolio.
Within the Respiratory Global Portfolio and Product Strategy (GPPS) team and reporting to the commercial VP, Fasenra, you will be the strategy and launch lead for the LCM indications.
You will be accountable for the development and implementation of the commercial strategy, including but not limited to, business opportunities identification, sizing and prioritization, go to market model definition, target patients and physicians understanding, local marketing companies’ engagement. You will represent the commercial voice in the GDT (Global Development Team) providing input and contributing to the decision making on future clinical development projects.
The successful individual will demonstrate strong skills in the areas of strategic thinking, decision making, communication, leadership, problem solving and collaboration.
Major Duties and Responsibilities:
As the global Head of Fasenra LCM you will represent GPPS and be accountable for:
Leading the LCM commercial strategy definition
Represent the commercial voice within the global cross functional product team
Engaging with the local BUHs to ensure alignment on the business cases and the prioritization among the different diseases
Engaging with KEEs to gather input and insight to inform the LCM strategy and activities plan including advocacy development
Supervise the forecasting and insight gathering activities for all the new diseases
Bringing the commercial perspective into the clinical trials design (eg TPP, dosing, comparator, potential claims etc..)
Start setting the strategy for the next indication launch (Nasal Polyps)
Education: Business degree is required with science expertise as preferred
Significant experience in healthcare or biopharma industry, with a strong preference for experience in the respiratory therapeutic area and biologic drugs.
Experience of shaping brand strategy whilst the understanding of product profile was incomplete and evolving
In-depth understanding of commercial strategy, methodologies and tools (product profiling and positioning, forecasting, pricing & reimbursement, market research techniques, competitive intelligence resources)
Thorough ‘hands-on’ knowledge of building TPPs, generating sales forecasts and business cases.
Thorough understanding of the drug development process and the need for commercial line of sight throughout
Understanding of future healthcare market challenges including local regulatory DO’s and DON’Ts
Exposure to and track record of effective management of senior decision-making/governance bodies
Proven experience of engaging with and leveraging insights from external customers e.g. KEEs, prescribers, payors
Strong strategic thinking, decision making, and problem solving
Strong leadership and influencing skills to ensure a strong commercial focus in R&D projects
Proven ability to collaborate across functional boundaries
Demonstrated ability to bring ideas to action
Strong analytical, organizational and communication skills (written and verbal) required
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.