AstraZeneca Pharmaceuticals LP Senior Scientist - Modelling and Simulation Specialist in Cambridge, United Kingdom

Position: Senior Scientist - Modelling and Simulation Specialist

Salary: Competitive

Location: Cambridge (UK), Gothenburg (Sweden)

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. Here, we see the impact of our collective ideas and expertise, and the power of science to deliver them.

We’re looking for a Modelling and Simulation scientist with a track record of developing and applying model-based approaches in the development of drugs to join Mechanistic Safety and ADME Sciences Department. As a Modelling and Simulation Specialist you’ll play a pivotal role in defining the way we use data and technology in the future.

The Mechanistic Safety and ADME Sciences team is responsible for running and interpreting cutting edge in vivo and in vitro systems for key target organs. This provides us with a wealth of information requiring identification of early predictors and patterns of activity associated with adverse drug events.

As a Modelling and Simulation Specialist your focus will be on pharmacology, toxicology and in vivo data. You’ll be responsible for the application of systems pharmacology and data science to evaluate and translate in vivo safety findings from preclinical species into patient populations. You’ll also engage with other toxicology and pharmacology scientists in providing holistic and quantitative safety risk assessments.

Your main challenge will be on developing and implementing systems pharmacology approaches in preclinical safety. Specifically, you’ll apply pharmacokinetics (PK) / pharmacodynamics (PD) and mechanistic modelling to in vivo and in vitro data to translate predictors of safety liabilities that can be applied to support projects. You’ll also work with computational specialists in other departments and institutions to coordinate the development and implementation of cross-functional collaborations. You’ll liaise with a variety of key stakeholders and collaborators to identify opportunities, build support and deliver innovative modelling and simulation solutions.

To succeed in this role, you’ll therefore need to work collaboratively with your key stakeholders and provide innovative solutions to challenging technical problems.

Main responsibilities:

  • Contributing to the development and implementation of new strategies for Translational Safety and Absorption, Distribution, Metabolism and Excretion (ADME)

  • Analysing outcomes of toxicology studies and developing preclinical models to enhance project decision-making

  • Working to optimise the impact of modelling in efficacy and safety studies

  • Evaluating and interpreting data to prepare for internal governance bodies

  • Contribute to development of ADME and Safety modelling platforms

Essential requirements:

  • Post-Graduate level education (or equivalent training / experience) in a relevant discipline

  • Knowledge and experience with the drug discovery/development process

  • Extensive Modelling and Simulation experience with PK/PD, PBPK or Systems Pharmacology

  • Exposure to current principles and concepts in DMPK and Safety Assessment

  • High degree of scientific leadership as evidenced by publication record

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.