AstraZeneca Pharmaceuticals LP Senior Research Scientists: PROTACS & Ubiquitin Biology in Cambridge, United Kingdom

Positions: Senior Research Scientists: PROTACS & Ubiquitin Biology.

Departments: Cellular Assay Development, and Mechanistic Biology & Profiling.

Location: Cambridge, UK.

Salary: Competitive & Excellent Benefits Package

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

As a Senior Research Scientist, in Cellular Assay Development or Mechanistic Biology & Profiling in Cambridge, UK, you’ll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients’ lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas.

The Cellular Assay Development group, within the Discovery Biology department of Discovery Sciences within IMED, is responsible for the generation of novel cellular assays to support projects in all phases of the drug discovery pipeline. Mechanistic Biology & Profiling (also part of Discovery Sciences), is a global, multidisciplinary department responsible for mechanism-of-action studies and compound profiling for efficacy and pre-clinical safety in support of the Oncology, Cardiovascular and Renal Disease, Respiratory, Inflammation & Autoimmunity, and Neuroscience portfolios.

We have 2 exciting opportunities for you to join Discovery Sciences as a lab-based scientist and be a key member of the team, developing state of the art cellular based screening assays and detailed mechanism-of-action studies in support of Oncology and Neuroscience drug discovery projects.

Specifically, the successful candidate will work in the area of ubiquitin biology, applying their skills to identify and characterise PROTAC lead molecules and their effect on underlying disease biology.

Main Duties and Responsibilities

  • To be a lab-based scientist, delivering expertise in the area of cellular assay development and ubiquitin biology; independently and creatively designing, developing and validating cellular assays for implementation in drug discovery projects.

  • To push the boundaries in the field of cellular assay development and cellular mechanism-of-action, while working in partnership with colleagues in the high-throughput screening and the mechanistic biology & profiling teams to ensure that assays are fit for purpose.

  • To implement work-plans over agreed timelines such that the objectives of the project are met, including delivery of more than one agreed area of work in parallel where appropriate.

  • To be an effective member of Drug Discovery Project Teams, contributing novel ideas and using judgment and knowledge where appropriate to influence the work of the project.

  • To maintain an awareness of current developments in the literature and contribute to the continuous improvement process by identifying opportunities in the workplace where improvements can be made; may lead one or more aspects of scientific discipline within their team.

  • To achieve personal scientific visibility through project contributions and internal presentations at departmental or functional meetings; and external scientific visibility through poster & oral conference presentations and authorship on peer-reviewed publications.

Essential Requirements

  • Ph.D in Biology, Pharmacology, Cell biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry.

  • Experience in molecular and cellular biology techniques applied to development of physiologically relevant cellular assays together with expertise in the design, development and validation of cellular assays for compound profiling and screening applications.

  • Experience in molecular and cellular biology techniques applied to detailed mechanism-of-action studies

  • Expertise in a range of cell biology techniques, to include cloning, transfection methods, gene expression knock-down (RNAi or other) and endogenous gene tagging.

  • A practical understanding of a wide range of cellular assay methods and technologies (for example fluorescence, luminescence, mass spectrometry and target engagement techniques) as applied to a range of biological targets.

  • Expertise in E3 Ligase biology possibly with proven experience on development of cellular assays capable of identifying PROTAC lead molecules

Desirable Requirements

  • Excellent problem-solving skills, strong delivery focus and communication skills.

  • Good publication records in peer-reviewed journals preferably in the field of ubiquitin biology

  • Research experience in Oncology or Neuroscience

  • Excellent team working and networking skills with experience of interacting effectively across interfaces of discipline, culture, and expertise.

  • Experience of working in external collaborations both in academia and pharmaceutical industry.

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.